Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50122758
Substrate
n/a
Meas. Tech.
ChEMBL_123595 (CHEMBL734177)
IC50
30000±n/a nM
Citation
 Cosford, ND; Tehrani, L; Roppe, J; Schweiger, E; Smith, ND; Anderson, J; Bristow, L; Brodkin, J; Jiang, X; McDonald, I; Rao, S; Washburn, M; Varney, MA 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-6 (2003) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_MOUSE | Amine oxidase [flavin-containing] A | MAO-A | Maoa | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:
PROTEIN
Mol. Mass.:
59608.24
Organism:
Mus musculus
Description:
ChEMBL_122776
Residue:
526
Sequence:
MTDLEKPSITGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDDMGKEIPVDAPWQARHAEEWDKITMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTSRIFSVTNGGQERKFVGGSGQISEQIMVLLGDKVKLSSPVTYIDQTDDNIIIETLNHEHYECKYVISAIPPVLTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSMPAIMGFILARKAERLAKLHKDIRKRKICELYAKVLGSQEALSPVHYEEKNWCEEQYSGGCYTAYFPPGIMTLYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVQEPESKDVPALEITHTFLERNLPSVPGLLKITGFSTSVALLCFVLYKFKQPQS
  
Inhibitor
Name:
BDBM50122758
Synonyms:
2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-(2-Methyl-thiazol-4-ylethynyl)-pyridine | 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine | 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine | CHEMBL292065 | MTEP
Type:
Small organic molecule
Emp. Form.:
C11H8N2S
Mol. Mass.:
200.26
SMILES:
Cc1nc(cs1)C#Cc1cccnc1
Structure:
Search PDB for entries with ligand similarity: