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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50560757
Substrate
n/a
Meas. Tech.
ChEMBL_2073005 (CHEMBL4728539)
IC50
79±n/a nM
Citation
Codony, S; Pujol, E; Pizarro, J; Feixas, F; Valverde, E; Loza, MI; Brea, JM; Saez, E; Oyarzabal, J; Pineda-Lucena, A; Pérez, B; Pérez, C; Rodríguez-Franco, MI; Leiva, R; Osuna, S; Morisseau, C; Hammock, BD; Vázquez-Carrera, M; Vázquez, S 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: J Med Chem 63:9237-9257 (2020) [PubMed] Article
More Info.:
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH)
Type:
Enzyme
Mol. Mass.:
62512.06
Organism:
Mus musculus (Mouse)
Description:
P34914
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITFSQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTCIVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQTEVQNPSVTSKI
Inhibitor
Name:
BDBM50560757
Synonyms:
CHEMBL4784283
Type:
Small organic molecule
Emp. Form.:
C18H31N3O4S
Mol. Mass.:
385.521
SMILES:
CC(C)S(=O)(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)O1)C2 |TLB:15:16:19.18.23:21,THB:17:18:21:25.16.24,17:16:19.18.23:21,24:16:19:23.22.21,24:22:19:25.17.16,15:16:19:23.22.21|