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Target
NAD(+) hydrolase SARM1
Ligand
BDBM50420356
Substrate
n/a
Meas. Tech.
ChEMBL_2074145 (CHEMBL4729679)
IC50
145000±n/a nM
Citation
 Loring, HS; Parelkar, SS; Mondal, S; Thompson, PR Identification of the first noncompetitive SARM1 inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
NAD(+) hydrolase SARM1
Synonyms:
3.2.2.- | 3.2.2.6 | HsTIR | KIAA0524 | MyD88-5 | NAD(+) hydrolase SARM1 | NADP(+) hydrolase SARM1 | NADase SARM1 | SAM domain-containing protein 2 | SAMD2 | SAMD2 GN | SARM | SARM1 | SARM1_HUMAN | Sterile alpha and Armadillo repeat protein | Sterile alpha and TIR motif-containing protein 1 | Sterile alpha motif domain-containing protein 2 | Synonyms=KIAA0524 | Tir-1 homolog | hSARM1
Type:
PROTEIN
Mol. Mass.:
79387.31
Organism:
Homo sapiens
Description:
ChEMBL_119100
Residue:
724
Sequence:
MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
  
Inhibitor
Name:
BDBM50420356
Synonyms:
NC 150 | PHENAZOPYRIDINE HYDROCHLORIDE
Type:
Small organic molecule
Emp. Form.:
C11H11N5
Mol. Mass.:
213.2385
SMILES:
Nc1ccc(\N=N\c2ccccc2)c(N)n1
Structure:
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