Reaction Details Report a problem with these data
Target
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Ligand
BDBM50562210
Substrate
n/a
Meas. Tech.
ChEMBL_2077733 (CHEMBL4733524)
IC50
>10000±n/a nM
Citation
 Yang, W; Liu, X; Song, C; Ji, S; Yang, J; Liu, Y; You, J; Zhang, J; Huang, S; Cheng, W; Shao, Z; Li, L; Yang, S Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Synonyms:
1.14.11.- | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | Histone arginine demethylase JMJD6 | JMJD6 | JMJD6_HUMAN | JmjC domain-containing protein 6 | Jumonji domain-containing protein 6 | KIAA0585 | Lysyl-hydroxylase JMJD6 | PSR | PTDSR | Peptide-lysine 5-dioxygenase JMJD6 | Phosphatidylserine receptor | Protein PTDSR | Synonyms=KIAA0585
Type:
PROTEIN
Mol. Mass.:
46472.03
Organism:
Homo sapiens
Description:
ChEMBL_119095
Residue:
403
Sequence:
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR
  
Inhibitor
Name:
BDBM50562210
Synonyms:
CHEMBL4754158
Type:
Small organic molecule
Emp. Form.:
C25H27N3S
Mol. Mass.:
401.567
SMILES:
CC(c1ccc(cc1)N1CCN(C)CC1)c1ccc2Sc3ccccc3Nc2c1
Structure:
Search PDB for entries with ligand similarity: