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Target
Glutamate receptor
Ligand
BDBM50126761
Substrate
n/a
Meas. Tech.
ChEMBL_90450 (CHEMBL699822)
EC50
4900±n/a nM
Citation
 Brehm, L; Greenwood, JR; Hansen, KB; Nielsen, B; Egebjerg, J; Stensbøl, TB; Bräuner-Osborne, H; Sløk, FA; Kronborg, TT; Krogsgaard-Larsen, P (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. J Med Chem 46:1350-8 (2003) [PubMed]  Article 
Target
Name:
Glutamate receptor
Synonyms:
Glutamate receptor ionotropic kainate 2
Type:
PROTEIN
Mol. Mass.:
102684.79
Organism:
Xenopus laevis
Description:
ChEMBL_90450
Residue:
908
Sequence:
MKIISPSLTNSFFRCTLRFVACLFWIGYSQGTTHVLRFGGIFESVESGPSGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASRKACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTIAYDDSTGLIRLQELIKAPSRYNLRLKIRQLPIDTKDAKPLLKEMKRGKEFHVIFDCSHDMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNLTGFRILNIENSQVLSIIEKWSMDRLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGSRFISLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDLTSGLNMTENQKGKPANITDSLSNRSLIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKLSRILGFEYEVRLVEDGKYGAKDDTTQQWNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
  
Inhibitor
Name:
BDBM50126761
Synonyms:
(S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID | 2-Amino-3-(5-tert-butyl-3-hydroxy-isothiazol-4-yl)-propionic acid | CHEMBL29024
Type:
Small organic molecule
Emp. Form.:
C10H16N2O3S
Mol. Mass.:
244.311
SMILES:
CC(C)(C)c1s[nH]c(=O)c1C[C@H](N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: