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Target
Glutamate receptor
Ligand
BDBM50126764
Substrate
n/a
Meas. Tech.
ChEMBL_90450 (CHEMBL699822)
EC50
6400±n/a nM
Citation
 Brehm, L; Greenwood, JR; Hansen, KB; Nielsen, B; Egebjerg, J; Stensbøl, TB; Bräuner-Osborne, H; Sløk, FA; Kronborg, TT; Krogsgaard-Larsen, P (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. J Med Chem 46:1350-8 (2003) [PubMed]  Article 
Target
Name:
Glutamate receptor
Synonyms:
Glutamate receptor ionotropic kainate 2
Type:
PROTEIN
Mol. Mass.:
102684.79
Organism:
Xenopus laevis
Description:
ChEMBL_90450
Residue:
908
Sequence:
MKIISPSLTNSFFRCTLRFVACLFWIGYSQGTTHVLRFGGIFESVESGPSGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASRKACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTIAYDDSTGLIRLQELIKAPSRYNLRLKIRQLPIDTKDAKPLLKEMKRGKEFHVIFDCSHDMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNLTGFRILNIENSQVLSIIEKWSMDRLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGSRFISLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDLTSGLNMTENQKGKPANITDSLSNRSLIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKLSRILGFEYEVRLVEDGKYGAKDDTTQQWNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
  
Inhibitor
Name:
BDBM50126764
Synonyms:
(S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid | 2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)-propionic acid | 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE | CHEMBL28472
Type:
Small organic molecule
Emp. Form.:
C11H14N2O4
Mol. Mass.:
238.2399
SMILES:
N[C@@H](CC1=CCCCc2o[nH]c(=O)c12)C(O)=O |t:3|
Structure:
Search PDB for entries with ligand similarity: