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Target
Cathepsin S
Ligand
BDBM50129070
Substrate
n/a
Meas. Tech.
ChEBML_48676
Ki
9.2±n/a nM
Citation
 Setti, EL; Davis, D; Chung, T; McCarter, J 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity. Bioorg Med Chem Lett 13:2051-3 (2003) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50129070
Synonyms:
Acetic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-4-methyl-1-oxo-pentylamino)-4-oxo-azetidin-2-yl ester | Acetic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-oxo-azetidin-2-yl ester | CHEMBL292513
Type:
Small organic molecule
Emp. Form.:
C19H25N3O6
Mol. Mass.:
391.4183
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H]1[C@@H](NC1=O)OC(C)=O
Structure:
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