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Target
Beta-3 adrenergic receptor
Ligand
BDBM50129443
Substrate
n/a
Meas. Tech.
ChEBML_41707
EC50
120±n/a nM
Citation
 Sum, FW; Wong, V; Han, S; Largis, E; Mulvey, R; Tillett, J Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists. Bioorg Med Chem Lett 13:2191-4 (2003) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50129443
Synonyms:
4-{(S)-2-Hydroxy-3-[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylamino]-propoxy}-1,3-dihydro-benzoimidazol-2-one | CHEMBL68685
Type:
Small organic molecule
Emp. Form.:
C22H28N4O6S
Mol. Mass.:
476.546
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
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