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Target
Vasopressin V2 receptor
Ligand
BDBM50065117
Substrate
n/a
Meas. Tech.
ChEBML_215009
IC50
13±n/a nM
Citation
 Sum, FW; Dusza, J; Santos, ED; Grosu, G; Reich, M; Du, X; Albright, JD; Chan, P; Coupet, J; Ru, X; Mazandarani, H; Saunders, T Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists. Bioorg Med Chem Lett 13:2195-8 (2003) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50065117
Synonyms:
CHEMBL304956 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-phenyl]-2,3-dimethyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C28H25N3O2
Mol. Mass.:
435.517
SMILES:
Cc1cccc(C(=O)Nc2ccc(cc2)C(=O)N2Cc3cccn3Cc3ccccc23)c1C
Structure:
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