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Target
Methionine--tRNA ligase, cytoplasmic
Ligand
BDBM50129540
Substrate
n/a
Meas. Tech.
ChEMBL_203520 (CHEMBL806984)
IC50
4460±n/a nM
Citation
 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett 13:2231-4 (2003) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase, cytoplasmic
Synonyms:
MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN
Type:
PROTEIN
Mol. Mass.:
101110.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105283
Residue:
900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
  
Inhibitor
Name:
BDBM50129540
Synonyms:
5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-hydroxy-ethyl)-1H-pyrazole-3-carboxylic acid | CHEMBL74009
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2N2O3
Mol. Mass.:
377.221
SMILES:
OCCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O
Structure:
Search PDB for entries with ligand similarity: