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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50131131
Substrate
n/a
Meas. Tech.
ChEBML_69451
Ki
8.8±n/a nM
Citation
 Das, J; Moquin, RV; Lin, J; Liu, C; Doweyko, AM; DeFex, HF; Fang, Q; Pang, S; Pitt, S; Shen, DR; Schieven, GL; Barrish, JC; Wityak, J Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors. Bioorg Med Chem Lett 13:2587-90 (2003) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50131131
Synonyms:
2-(6-Methylamino-pyrimidin-4-ylamino)-benzothiazole-6-carboxylic acid (2-chloro-6-methyl-phenyl)-amide | CHEMBL90002
Type:
Small organic molecule
Emp. Form.:
C20H17ClN6OS
Mol. Mass.:
424.907
SMILES:
CNc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)ncn1
Structure:
Search PDB for entries with ligand similarity: