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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50221044
Substrate
n/a
Meas. Tech.
ChEMBL_44674 (CHEMBL656547)
IC50
<28±n/a nM
Citation
 Baxter, A; Bennion, C; Bent, J; Boden, K; Brough, S; Cooper, A; Kinchin, E; Kindon, N; McInally, T; Mortimore, M; Roberts, B; Unitt, J Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists. Bioorg Med Chem Lett 13:2625-8 (2003) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50221044
Synonyms:
CHEMBL309253
Type:
Small organic molecule
Emp. Form.:
C15H11Cl2N3S
Mol. Mass.:
336.239
SMILES:
Sc1nc(nn1Cc1cccc(Cl)c1)-c1ccccc1Cl
Structure:
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