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Target
Bcl-2-like protein 1
Ligand
BDBM50566652
Substrate
n/a
Meas. Tech.
ChEMBL_2101456 (CHEMBL4809852)
Kd
96±n/a nM
Citation
 Daguer, JP; Gonse, A; Shchukin, Y; Farrera-Soler, L; Barluenga, S; Winssinger, N Dual Bcl-X Bioorg Med Chem 44:0 (2021) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50566652
Synonyms:
CHEMBL4871228
Type:
Small organic molecule
Emp. Form.:
C45H51ClN10O9S2
Mol. Mass.:
975.531
SMILES:
[H][C@]12CS[C@@H](CCCCCC(=O)NC(=O)C(CNC(=O)C(NC3=NS(=O)(=O)c4ccccc34)C(C)C)NC(=O)C3(CC3)NC(=O)COc3ccccc3-c3n[nH]c4ccc(Cl)cc34)[C@@]1([H])NC(=O)N2 |r,t:22|
Structure:
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