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Target
GTPase KRas
Ligand
BDBM50567176
Substrate
n/a
Meas. Tech.
ChEMBL_2102480 (CHEMBL4810876)
IC50
0.900000±n/a nM
Citation
 Kargbo, RB Small Molecule Inhibitors of KRAS Mutant as a Therapeutic Strategy for the Treatment of Cancer. ACS Med Chem Lett 12:1183-1185 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50567176
Synonyms:
CHEMBL4856826
Type:
Small organic molecule
Emp. Form.:
C31H38ClN9O2
Mol. Mass.:
604.146
SMILES:
C[C@H](CN(C)C)NC(=O)c1cc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2CCN(Cc2n1)c1c(Cl)c(C)cc2[nH]ncc12 |r|
Structure:
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