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Target
Choline kinase alpha
Ligand
BDBM50131885
Substrate
n/a
Meas. Tech.
ChEMBL_49273 (CHEMBL662980)
IC50
300±n/a nM
Citation
 Conejo-García, A; Campos, JM; Sánchez-Martín, RM; Gallo, MA; Espinosa, A Bispyridinium cyclophanes: novel templates for human choline kinase inhibitors. J Med Chem 46:3754-7 (2003) [PubMed]  Article 
Target
Name:
Choline kinase alpha
Synonyms:
CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha
Type:
PROTEIN
Mol. Mass.:
52248.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290064
Residue:
457
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
  
Inhibitor
Name:
BDBM50131885
Synonyms:
4,8-diaza-3 (1,4) , 9 (4,1)-dipyridina-1 (1,4), 6 (1,3) -dibenzenacyclodecaphan-3,9-bis (ilium) dibromide | CHEMBL125148
Type:
Small organic molecule
Emp. Form.:
C26H26N4
Mol. Mass.:
394.5103
SMILES:
C1N[c+]2ccn(Cc3ccc(Cn4cc[c+](NCc5cccc1c5)cc4)cc3)cc2
Structure:
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