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Target
Cyclin-C
Ligand
BDBM50567870
Substrate
n/a
Meas. Tech.
ChEMBL_2103907 (CHEMBL4812410)
Ki
7.0±n/a nM
Citation
 Yu, M; Long, Y; Yang, Y; Li, M; Teo, T; Noll, B; Philip, S; Wang, S Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50567870
Synonyms:
CHEMBL4867449
Type:
Small organic molecule
Emp. Form.:
C21H21ClN4OS
Mol. Mass.:
412.936
SMILES:
Nc1ncc(-c2cc3ccccc3s2)c(N2CCC3(CCNC3=O)CC2)c1Cl
Structure:
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