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Target
Adenosine kinase
Ligand
BDBM50132283
Substrate
n/a
Meas. Tech.
ChEMBL_31131 (CHEMBL643559)
IC50
10±n/a nM
Citation
 Zheng, GZ; Mao, Y; Lee, CH; Pratt, JK; Koenig, JR; Perner, RJ; Cowart, MD; Gfesser, GA; McGaraughty, S; Chu, KL; Zhu, C; Yu, H; Kohlhaas, K; Alexander, KM; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Stewart, AO Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity. Bioorg Med Chem Lett 13:3041-4 (2003) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50132283
Synonyms:
5-(3-Bromo-phenyl)-7-[6-(4-ethoxy-piperidin-1-yl)-pyridazin-3-yl]-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL106386
Type:
Small organic molecule
Emp. Form.:
C24H24BrN7O
Mol. Mass.:
506.398
SMILES:
CCOC1CCN(CC1)c1ccc(nn1)-c1cc(-c2cccc(Br)c2)c2c(N)ncnc2n1
Structure:
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