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Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50132713
Substrate
n/a
Meas. Tech.
ChEBML_68783
IC50
2.5±n/a nM
Citation
 Segall, Y; Quistad, GB; Nomura, DK; Casida, JE Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett 13:3301-3 (2003) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM50132713
Synonyms:
Arachidonic acid derivative | CHEMBL113262 | Methyl arachidonoyl fluorophophonate | methyl ((5Z,8Z,11Z,14Z)-2-Icosa-5,8,11,14-tetraenyl)phosphonofluoridoate | methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate | methyl -icosa-5,8,11,14-tetraenylphosphonofluoridate | methyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate | methylarachidonyl fluorophosphonate
Type:
Small organic molecule
Emp. Form.:
C21H36FO2P
Mol. Mass.:
370.4815
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Structure:
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