Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132884
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
64±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132884
Synonyms:
CHEMBL116010 | Dibutyl-[3-(2,4-dichloro-phenyl)-5-methyl-2-propyl-2H-pyrazolo[4,3-b]pyridin-7-yl]-amine
Type:
Small organic molecule
Emp. Form.:
C24H32Cl2N4
Mol. Mass.:
447.444
SMILES:
CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CCC)nc12 |(9.01,4.85,;8.05,3.64,;8.61,2.22,;7.64,1.02,;8.19,-.4,;9.72,-.64,;10.68,.56,;12.19,.33,;13.16,1.53,;7.23,-1.6,;7.8,-3.03,;6.84,-4.22,;7.4,-5.66,;5.31,-3.98,;4.75,-2.57,;3.33,-2.02,;2.09,-2.91,;2.26,-4.45,;1.01,-5.36,;-.4,-4.73,;-1.64,-5.64,;-.56,-3.21,;.68,-2.29,;.53,-.75,;3.4,-.51,;2.19,.44,;2.43,1.97,;1.22,2.92,;4.87,-.1,;5.71,-1.37,)|
Structure:
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