Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132887
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
28±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132887
Synonyms:
CHEMBL115313 | Dibutyl-[2,5-dimethyl-3-(2,4,6-trimethyl-phenyl)-2H-pyrazolo[4,3-b]pyridin-7-yl]-amine
Type:
Small organic molecule
Emp. Form.:
C25H36N4
Mol. Mass.:
392.5801
SMILES:
CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 |(16.55,-8.33,;16.01,-6.88,;14.49,-6.64,;13.93,-5.21,;12.41,-4.96,;11.85,-3.54,;12.81,-2.34,;12.25,-.9,;10.73,-.66,;11.43,-6.18,;11.99,-7.6,;11.04,-8.81,;11.6,-10.24,;9.51,-8.58,;8.95,-7.13,;7.51,-6.6,;6.27,-7.48,;4.86,-6.87,;4.68,-5.34,;3.61,-7.78,;3.77,-9.31,;2.52,-10.22,;5.17,-9.94,;6.43,-9.03,;7.85,-9.66,;7.58,-5.08,;6.36,-4.12,;9.05,-4.66,;9.91,-5.94,)|
Structure:
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