Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132888
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
32±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132888
Synonyms:
Butyl-[3-(2,4-dichloro-phenyl)-2-ethyl-5-methyl-2H-pyrazolo[4,3-b]pyridin-7-yl]-ethyl-amine | CHEMBL419761
Type:
Small organic molecule
Emp. Form.:
C21H26Cl2N4
Mol. Mass.:
405.364
SMILES:
CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 |(8.98,6.26,;8.02,5.05,;8.58,3.61,;7.61,2.42,;8.17,.99,;9.68,.75,;10.65,1.95,;7.19,-.22,;7.76,-1.64,;6.79,-2.84,;7.35,-4.27,;5.28,-2.61,;4.72,-1.17,;3.27,-.64,;2.04,-1.54,;2.2,-3.06,;.96,-3.97,;-.46,-3.34,;-1.7,-4.25,;-.62,-1.82,;.64,-.91,;.47,.63,;3.34,.88,;2.14,1.83,;2.38,3.36,;4.82,1.3,;5.67,.02,)|
Structure:
Search PDB for entries with ligand similarity: