Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132897
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
80±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132897
Synonyms:
Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-b]pyridin-7-yl]-[2-(4-methoxy-phenyl)-ethyl]-amine | CHEMBL325996
Type:
Small organic molecule
Emp. Form.:
C27H30Cl2N4O
Mol. Mass.:
497.459
SMILES:
CCCCN(CCc1ccc(OC)cc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 |(12.2,6.71,;11.25,5.52,;11.81,4.07,;10.83,2.88,;11.39,1.45,;12.9,1.2,;13.46,-.23,;14.98,-.47,;15.53,-1.9,;17.05,-2.15,;18.01,-.94,;19.53,-1.17,;20.5,.02,;17.45,.51,;15.93,.74,;10.42,.25,;10.99,-1.19,;10.03,-2.39,;10.59,-3.82,;8.5,-2.15,;7.94,-.72,;6.51,-.17,;5.27,-1.08,;5.43,-2.61,;4.18,-3.52,;2.77,-2.89,;1.52,-3.8,;2.61,-1.36,;3.86,-.45,;3.71,1.09,;6.58,1.34,;5.37,2.3,;8.05,1.75,;8.89,.48,)|
Structure:
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