Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132900
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
32±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132900
Synonyms:
CHEMBL114821 | [3-(2-Chloro-4-methyl-phenyl)-2-ethyl-5-methyl-2H-pyrazolo[4,3-b]pyridin-7-yl]-cyclopropylmethyl-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C23H29ClN4
Mol. Mass.:
396.956
SMILES:
CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(C)cc3Cl)n(CC)nc12 |(8.86,4.53,;9.42,3.1,;8.46,1.89,;9.02,.46,;10.54,.23,;11.1,-1.22,;12.62,-1.46,;10.13,-2.41,;8.05,-.75,;8.61,-2.18,;7.65,-3.37,;8.21,-4.82,;6.12,-3.14,;5.56,-1.71,;4.12,-1.17,;2.88,-2.06,;3.05,-3.61,;1.78,-4.52,;.38,-3.89,;-.86,-4.79,;.22,-2.36,;1.47,-1.43,;1.31,.09,;4.19,.35,;2.98,1.31,;3.21,2.84,;5.66,.76,;6.52,-.51,)|
Structure:
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