Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50132903
Substrate
n/a
Meas. Tech.
ChEBML_51133
Ki
70±n/a nM
Citation
 Wilcoxen, K; Huang, CQ; McCarthy, JR; Grigoriadis, DE; Chen, C Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists. Bioorg Med Chem Lett 13:3367-70 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50132903
Synonyms:
CHEMBL116011 | Dibutyl-[3-(2-chloro-4-methoxy-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-b]pyridin-7-yl]-amine
Type:
Small organic molecule
Emp. Form.:
C23H31ClN4O
Mol. Mass.:
414.971
SMILES:
CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(OC)cc3Cl)n(C)nc12 |(16.56,-7.58,;16.02,-6.13,;14.5,-5.9,;13.94,-4.47,;12.42,-4.22,;11.85,-2.79,;12.82,-1.59,;12.26,-.15,;10.74,.09,;11.44,-5.43,;12,-6.86,;11.04,-8.07,;11.61,-9.5,;9.52,-7.83,;8.96,-6.39,;7.51,-5.85,;6.27,-6.76,;6.44,-8.28,;5.18,-9.2,;3.77,-8.57,;2.53,-9.48,;2.69,-11.01,;3.61,-7.04,;4.86,-6.13,;4.68,-4.59,;7.58,-4.33,;6.37,-3.37,;9.06,-3.91,;9.91,-5.2,)|
Structure:
Search PDB for entries with ligand similarity: