Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50568747
Substrate
n/a
Meas. Tech.
ChEMBL_2106796 (CHEMBL4815471)
Ki
44±n/a nM
Citation
 Biselli, S; Bresinsky, M; Tropmann, K; Forster, L; Honisch, C; Buschauer, A; Bernhardt, G; Pockes, S Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H Eur J Med Chem 214:0 (2021) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50568747
Synonyms:
CHEMBL4876025
Type:
Small organic molecule
Emp. Form.:
C22H26N6OS
Mol. Mass.:
422.546
SMILES:
Cc1nc(N)sc1CCCN\C(N)=N\C(=O)NC(c1ccccc1)c1ccccc1
Structure:
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