Reaction Details Report a problem with these data
Target
Type 1 fimbrin D-mannose specific adhesin
Ligand
BDBM50570118
Substrate
n/a
Meas. Tech.
ChEMBL_2111152 (CHEMBL4820002)
Kd
79±n/a nM
Citation
 Toma?i?, T; Rabbani, S; Jakob, RP; Reisner, A; Jakopin, ?; Maier, T; Ernst, B; Anderluh, M Does targeting Arg98 of FimH lead to high affinity antagonists? Eur J Med Chem 211:0 (2021) [PubMed]  Article 
Target
Name:
Type 1 fimbrin D-mannose specific adhesin
Synonyms:
Adhesin protein fimH | FIMH_ECOLI | fimH
Type:
PROTEIN
Mol. Mass.:
31474.61
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_1298296
Residue:
300
Sequence:
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
  
Inhibitor
Name:
BDBM50570118
Synonyms:
CHEMBL4876354
Type:
Small organic molecule
Emp. Form.:
C19H25N3O8
Mol. Mass.:
423.4171
SMILES:
OC[C@H]1O[C@@H]([C@@H](O)[C@@H](O)[C@@H]1O)n1cc(nn1)-c1cccc(OCCCCC(O)=O)c1 |r|
Structure:
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