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Target
Carboxypeptidase A1
Ligand
BDBM50121929
Substrate
n/a
Meas. Tech.
ChEMBL_45620 (CHEMBL655431)
IC50
400±n/a nM
Citation
 Barrow, JC; Nantermet, PG; Stauffer, SR; Ngo, PL; Steinbeiser, MA; Mao, SS; Carroll, SS; Bailey, C; Colussi, D; Bosserman, M; Burlein, C; Cook, JJ; Sitko, G; Tiller, PR; Miller-Stein, CM; Rose, M; McMasters, DR; Vacca, JP; Selnick, HG Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem 46:5294-7 (2003) [PubMed]  Article 
Target
Name:
Carboxypeptidase A1
Synonyms:
CBPA1_HUMAN | CPA | CPA1
Type:
PROTEIN
Mol. Mass.:
47132.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1496378
Residue:
419
Sequence:
MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY
  
Inhibitor
Name:
BDBM50121929
Synonyms:
(phenylmethyl)butanedioic acid | 2-benzylbutanedioic acid | 2-benzylsuccinic acid | CHEMBL151284 | alpha-benzylsuccinic acid | benzylsuccinic acid | beta-carboxybenzenebutanoic acid
Type:
Small organic molecule
Emp. Form.:
C11H12O4
Mol. Mass.:
208.2106
SMILES:
OC(=O)CC(Cc1ccccc1)C(O)=O
Structure:
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