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Target
Tyrosine-protein kinase Fgr
Ligand
BDBM50571039
Substrate
n/a
Meas. Tech.
ChEMBL_2113640 (CHEMBL4822490)
IC50
5.4±n/a nM
Citation
 Qiu, H; Ali, Z; Bender, A; Caldwell, R; Chen, YY; Fang, Z; Gardberg, A; Glaser, N; Goettsche, A; Goutopoulos, A; Grenningloh, R; Hanschke, B; Head, J; Johnson, T; Jones, C; Jones, R; Kulkarni, S; Maurer, C; Morandi, F; Neagu, C; Poetzsch, S; Potnick, J; Schmidt, R; Roe, K; Viacava Follis, A; Wing, C; Zhu, X; Sherer, B Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors. Bioorg Med Chem 40:0 (2021) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fgr
Synonyms:
FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr
Type:
protein
Mol. Mass.:
59469.88
Organism:
Homo sapiens (Human)
Description:
P09769
Residue:
529
Sequence:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
  
Inhibitor
Name:
BDBM50571039
Synonyms:
CHEMBL4877846
Type:
Small organic molecule
Emp. Form.:
C32H38N8O2
Mol. Mass.:
566.6965
SMILES:
CC(C)n1nc(C)c(c1C)-c1nc2c(ccnc2[nH]1)-c1ccc2[C@@H](CCCCc2c1)NC(=O)c1nc(no1)C(C)(C)C |r|
Structure:
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