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Target
Neutral amino acid transporter B(0)
Ligand
BDBM50571063
Substrate
n/a
Meas. Tech.
ChEMBL_2113702 (CHEMBL4822552)
IC50
8100±n/a nM
Citation
 Maffuid, KA; Koyioni, M; Torrice, CD; Murphy, WA; Mewada, HK; Koutentis, PA; Crona, DJ; Asquith, CRM Design and evaluation of 1,2,3-dithiazoles and fused 1,2,4-dithiazines as anti-cancer agents. Bioorg Med Chem Lett 43:0 (2021) [PubMed]  Article 
Target
Name:
Neutral amino acid transporter B(0)
Synonyms:
AAAT_HUMAN | ASCT2 | ASCT2 | ATB(0) | Baboon M7 virus receptor | M7V1 | Neutral amino acid transporter B(0) | RD114/simian type D retrovirus receptor | RDR | RDRC | SLC1A5 | Sodium-dependent neutral amino acid transporter type 2 | Solute carrier family 1 member 5
Type:
PROTEIN
Mol. Mass.:
56592.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109758
Residue:
541
Sequence:
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
  
Inhibitor
Name:
BDBM50571063
Synonyms:
CHEMBL4867768
Type:
Small organic molecule
Emp. Form.:
C11H9Cl2F3N2OS2
Mol. Mass.:
377.233
SMILES:
CC.FC(F)(F)Oc1ccc(cc1Cl)\N=c1/ssnc1Cl
Structure:
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