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Target
Coagulation factor X
Ligand
BDBM50113865
Substrate
n/a
Meas. Tech.
ChEMBL_49306 (CHEMBL663405)
Ki
23±n/a nM
Citation
 Ostrovsky, D; Udier-Blagovic, M; Jorgensen, WL Analyses of activity for factor Xa inhibitors based on Monte Carlo simulations. J Med Chem 46:5691-9 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50113865
Synonyms:
3-[6-(5-Carbamimidoyl-2,3-dihydroxy-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide | CHEMBL82456
Type:
Small organic molecule
Emp. Form.:
C22H20F2N4O5
Mol. Mass.:
458.4148
SMILES:
CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(cc(O)c3O)C(N)=N)c(F)c(C)c2F)c1
Structure:
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