Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM50572118
Substrate
n/a
Meas. Tech.
ChEMBL_2116283 (CHEMBL4825224)
IC50
0.560000±n/a nM
Citation
 Kargbo, RB Small Molecule Inhibitors of KRAS G12C Mutant. ACS Med Chem Lett 12:1210-1211 (2021) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50572118
Synonyms:
CHEMBL4856277
Type:
Small organic molecule
Emp. Form.:
C33H32ClF3N6O3
Mol. Mass.:
653.094
SMILES:
CC(C)c1nccc2CCC(F)(F)COc3cccc(F)c3-c3nc4n(-c12)c(=O)nc(N1CCN(C[C@@H]1C)C(=O)C=C)c4cc3Cl |r|
Structure:
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