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Target
Histone deacetylase 1
Ligand
BDBM50137833
Substrate
n/a
Meas. Tech.
ChEBML_87538
IC50
4000±n/a nM
Citation
 Vaisburg, A; Bernstein, N; Frechette, S; Allan, M; Abou-Khalil, E; Leit, S; Moradei, O; Bouchain, G; Wang, J; Woo, SH; Fournel, M; Yan, PT; Trachy-Bourget, MC; Kalita, A; Beaulieu, C; Li, Z; MacLeod, AR; Besterman, JM; Delorme, D (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. Bioorg Med Chem Lett 14:283-7 (2003) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50137833
Synonyms:
6-(5-Hydroxy-6-morpholin-4-ylmethyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexanoic acid (2-amino-phenyl)-amide | CHEMBL419886
Type:
Small organic molecule
Emp. Form.:
C25H30N4O5
Mol. Mass.:
466.5295
SMILES:
Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cc(O)c(CN3CCOCC3)cc2C1=O
Structure:
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