Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50137869
Substrate
n/a
Meas. Tech.
ChEBML_163993
IC50
>50000±n/a nM
Citation
 Summa, V; Petrocchi, A; Pace, P; Matassa, VG; De Francesco, R; Altamura, S; Tomei, L; Koch, U; Neuner, P Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem 47:14-7 (2003) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50137869
Synonyms:
2,4-Dioxo-4-pyridin-3-yl-butyric acid | CHEMBL177968 | CHEMBL2040556
Type:
Small organic molecule
Emp. Form.:
C9H7NO4
Mol. Mass.:
193.1562
SMILES:
OC(=O)C(=O)CC(=O)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: