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Target
Fusion glycoprotein F0
Ligand
BDBM50572449
Substrate
n/a
Meas. Tech.
ChEMBL_2116840 (CHEMBL4825906)
IC50
1.5±n/a nM
Citation
 Cockerill, GS; Angell, RM; Bedernjak, A; Chuckowree, I; Fraser, I; Gascon-Simorte, J; Gilman, MSA; Good, JAD; Harland, R; Johnson, SM; Ludes-Meyers, JH; Littler, E; Lumley, J; Lunn, G; Mathews, N; McLellan, JS; Paradowski, M; Peeples, ME; Scott, C; Tait, D; Taylor, G; Thom, M; Thomas, E; Villalonga Barber, C; Ward, SE; Watterson, D; Williams, G; Young, P; Powell, K Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem 64:3658-3676 (2021) [PubMed]  Article 
Target
Name:
Fusion glycoprotein F0
Synonyms:
F | FUS_HRSVA | Fusion glycoprotein F0 | Fusion glycoprotein F1 | Fusion glycoprotein F2 | Intervening segment | Pep27 | Peptide 27 | p27
Type:
PROTEIN
Mol. Mass.:
63471.29
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_116942
Residue:
574
Sequence:
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
  
Inhibitor
Name:
BDBM50572449
Synonyms:
CHEMBL4853602
Type:
Small organic molecule
Emp. Form.:
C23H25FN4O2
Mol. Mass.:
408.4686
SMILES:
NCc1ccc2n(CCCCO)c(CN3C(=O)C4(CC4)c4ccc(F)cc34)nc2c1
Structure:
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