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Target
Calcium/calmodulin-dependent protein kinase kinase 1
Ligand
BDBM50271789
Substrate
n/a
Meas. Tech.
ChEMBL_2118551 (CHEMBL4827617)
IC50
195±n/a nM
Citation
 Eduful, BJ; O'Byrne, SN; Temme, L; Asquith, CRM; Liang, Y; Picado, A; Pilotte, JR; Hossain, MA; Wells, CI; Zuercher, WJ; Catta-Preta, CMC; Zonzini Ramos, P; Santiago, AS; Couņago, RM; Langendorf, CG; Nay, K; Oakhill, JS; Pulliam, TL; Lin, C; Awad, D; Willson, TM; Frigo, DE; Scott, JW; Drewry, DH Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem 64:10849-10877 (2021) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase kinase 1
Synonyms:
CAMKK1 | CAMKKA | CaM-kinase kinase alpha | KKCC1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55727.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774623
Residue:
505
Sequence:
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLVKEGFGEGGKSPELPGVQEDEAAS
  
Inhibitor
Name:
BDBM50271789
Synonyms:
CHEMBL4125686
Type:
Small organic molecule
Emp. Form.:
C19H18N2O2
Mol. Mass.:
306.3584
SMILES:
OC(=O)c1ccc(cc1C1CCCC1)-c1c[nH]c2ncccc12
Structure:
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