Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50139385
Substrate
n/a
Meas. Tech.
ChEMBL_83647 (CHEMBL693107)
Ki
3.5±n/a nM
Citation
 Cowart, M; Pratt, JK; Stewart, AO; Bennani, YL; Esbenshade, TA; Hancock, AA A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans. Bioorg Med Chem Lett 14:689-93 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50139385
Synonyms:
CHEMBL346562 | {4-[2-(2-Azepan-1-yl-ethyl)-benzofuran-5-yl]-phenyl}-morpholin-4-yl-methanone
Type:
Small organic molecule
Emp. Form.:
C27H32N2O3
Mol. Mass.:
432.5546
SMILES:
O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2oc(CCN3CCCCCC3)cc2c1
Structure:
Search PDB for entries with ligand similarity: