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Target
Cathepsin K
Ligand
BDBM50139496
Substrate
n/a
Meas. Tech.
ChEBML_45550
IC50
1.1±n/a nM
Citation
 Catalano, JG; Deaton, DN; Long, ST; McFadyen, RB; Miller, LR; Payne, JA; Wells-Knecht, KJ; Wright, LL Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 14:719-22 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50139496
Synonyms:
(R)-4,4-dimethyl-1-phenylpentan-3-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | CHEMBL349045 | [(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid (R)-2,2-dimethyl-1-phenethyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C29H40N2O4
Mol. Mass.:
480.6389
SMILES:
CCCC[C@H](NC(=O)O[C@H](CCc1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Structure:
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