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Target
Proteasome subunit beta type-9
Ligand
BDBM50573696
Substrate
n/a
Meas. Tech.
ChEMBL_2120236 (CHEMBL4829383)
IC50
33±n/a nM
Citation
 Lee, MJ; Bhattarai, D; Jang, H; Baek, A; Yeo, IJ; Lee, S; Miller, Z; Lee, S; Hong, JT; Kim, DE; Lee, W; Kim, KB Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease. J Med Chem 64:10934-10950 (2021) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50573696
Synonyms:
CHEMBL4877277
Type:
Small organic molecule
Emp. Form.:
C34H43N3O6
Mol. Mass.:
589.7217
SMILES:
[H][C@@]12CCCN1C(=O)CCCCCCCOc1ccc(C[C@H](NC2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r|
Structure:
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