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Target
Testis-specific serine/threonine-protein kinase 1
Ligand
BDBM50573869
Substrate
n/a
Meas. Tech.
ChEMBL_2120898 (CHEMBL4830045)
IC50
>10000±n/a nM
Citation
 Che, J; Dai, X; Gao, J; Sheng, H; Zhan, W; Lu, Y; Li, D; Gao, Z; Jin, Z; Chen, B; Luo, P; Yang, B; Hu, Y; He, Q; Weng, Q; Dong, X Discovery of  J Med Chem 64:12163-12180 (2021) [PubMed]  Article 
Target
Name:
Testis-specific serine/threonine-protein kinase 1
Synonyms:
SPOGA1 | SPOGA4 | STK22A | STK22D | TSSK1 | TSSK1B | TSSK1_HUMAN | Testis-specific serine/threonine-protein kinase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41624.03
Organism:
Homo sapiens (Human)
Description:
gi_14042947
Residue:
367
Sequence:
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
  
Inhibitor
Name:
BDBM50573869
Synonyms:
CHEMBL4556790
Type:
Small organic molecule
Emp. Form.:
C22H22ClF3N4O
Mol. Mass.:
450.884
SMILES:
Cl.Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 |r|
Structure:
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