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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50574075
Substrate
n/a
Meas. Tech.
ChEMBL_2121813 (CHEMBL4830960)
Ki
4300±n/a nM
Citation
 Yang, F; Su, H; Deng, J; Mou, L; Wang, H; Li, R; Dai, QQ; Yan, YH; Qian, S; Wang, Z; Li, GB; Yang, L Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates. Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50574075
Synonyms:
CHEMBL4856582
Type:
Small organic molecule
Emp. Form.:
C59H84N10O14
Mol. Mass.:
1157.3569
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CNCc1ccccc1)C(C)C)C(=O)N[C@@H](CCCCNC(=O)CCC(C)(C(O)=O)c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C(C)C)C(N)=O |r|
Structure:
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