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Target
Serine/threonine-protein kinase Nek2
Ligand
BDBM50574084
Substrate
n/a
Meas. Tech.
ChEMBL_2121875 (CHEMBL4831022)
IC50
3.2±n/a nM
Citation
 Zhang, L; Lakkaniga, NR; Bharate, JB; Mcconnell, N; Wang, X; Kharbanda, A; Leung, YK; Frett, B; Shah, NP; Li, HY Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor. Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek2
Synonyms:
NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:
Enzyme
Mol. Mass.:
51776.96
Organism:
Homo sapiens (Human)
Description:
P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM50574084
Synonyms:
CHEMBL4860697
Type:
Small organic molecule
Emp. Form.:
C28H27F3N6O2S
Mol. Mass.:
568.613
SMILES:
C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2cc(ccn12)-c1cnn(CCN(C)C)c1)c1ccccc1C(F)(F)F |r|
Structure:
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