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Target
Lysine-specific demethylase 4D
Ligand
BDBM50574737
Substrate
n/a
Meas. Tech.
ChEMBL_2123087 (CHEMBL4832320)
IC50
192±n/a nM
Citation
 Fang, Z; Liu, Y; Zhang, R; Chen, Q; Wang, T; Yang, W; Fan, Y; Yu, C; Xiang, R; Yang, S Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4D
Synonyms:
JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:
PROTEIN
Mol. Mass.:
58627.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102441
Residue:
523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
  
Inhibitor
Name:
BDBM50574737
Synonyms:
CHEMBL4847665
Type:
Small organic molecule
Emp. Form.:
C23H27FN2O5
Mol. Mass.:
430.4693
SMILES:
CC(C)(C)OC(=O)N[C@@H]1CCN(C1)C(c1ccc(F)cc1)c1cc2OCOc2cc1O |r|
Structure:
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