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Target
Phenylalanine--tRNA ligase alpha subunit
Ligand
BDBM50140715
Substrate
n/a
Meas. Tech.
ChEBML_154869
IC50
>100000±n/a nM
Citation
 Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg Med Chem Lett 14:1339-42 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase alpha subunit
Synonyms:
Phenylalanyl-tRNA synthetase alpha chain | SYFA_STRP8 | pheS
Type:
PROTEIN
Mol. Mass.:
39288.40
Organism:
Streptococcus pyogenes serotype M18
Description:
ChEMBL_154869
Residue:
347
Sequence:
MDLQAQLEELKTKTLETLQSLTGNHTKELQDLRVAVLGKKGSLTELLKGLKDLSNDLRPVVGKQVNEVRDLLTKAFEEQAKIVEAAKIQAQLDAESIDVTLPGRQMTLGHRHVLTQTSEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEEILLRTHTSPVQARTLDQHDFSKGPLKMVSPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMRDLKGTLEMIIKKMFGEERSIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVDAKEYSGFAFGLGQERIAMLRYGINDIRGFYQGDQRFSEQFN
  
Inhibitor
Name:
BDBM50140715
Synonyms:
3-(4-chlorophenyl)-5-(4-chloro-3-trifluoromethylphenyl)-(3R,3aS,6aR)-spiro[perhydrofuro[3,4-c]pyrrole-1,2'-(2',3'-dihydro-1'H-indene)]-1',3',4,6-tetraone | CHEMBL282736
Type:
Small organic molecule
Emp. Form.:
C27H14Cl2F3NO5
Mol. Mass.:
560.305
SMILES:
Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(c1)C(F)(F)F)c1ccc(Cl)cc1
Structure:
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