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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50140794
Substrate
n/a
Meas. Tech.
ChEMBL_44673 (CHEMBL656546)
IC50
18200±n/a nM
Citation
 Widdowson, KL; Elliott, JD; Veber, DF; Nie, H; Rutledge, MC; McCleland, BW; Xiang, JN; Jurewicz, AJ; Hertzberg, RP; Foley, JJ; Griswold, DE; Martin, L; Lee, JM; White, JR; Sarau, HM Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem 47:1319-21 (2004) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50140794
Synonyms:
1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea | 1-(2-hydroxy-4-nitrophenyl)-3-phenylurea | CHEMBL280711
Type:
Small organic molecule
Emp. Form.:
C13H11N3O4
Mol. Mass.:
273.2441
SMILES:
Oc1cc(ccc1NC(=O)Nc1ccccc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: