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Target
Dual specificity mitogen-activated protein kinase kinase 1
Ligand
BDBM50141404
Substrate
n/a
Meas. Tech.
ChEBML_124012
IC50
14±n/a nM
Citation
 Wityak, J; Hobbs, FW; Gardner, DS; Santella, JB; Petraitis, JJ; Sun, JH; Favata, MF; Daulerio, AJ; Horiuchi, KY; Copeland, RA; Scherle, PA; Jaffe, BD; Trzaskos, JM; Magolda, RL; Trainor, GL; Duncia, JV Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors. Bioorg Med Chem Lett 14:1483-6 (2004) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2
Type:
Other Protein Type
Mol. Mass.:
43439.03
Organism:
Homo sapiens (Human)
Description:
Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
  
Inhibitor
Name:
BDBM50141404
Synonyms:
4-({3-[(Z)-2-Amino-2-(2-amino-phenylsulfanyl)-1-cyano-vinyl]-phenyl}-hydroxy-methyl)-benzoic acid methyl ester | CHEMBL290865
Type:
Small organic molecule
Emp. Form.:
C24H21N3O3S
Mol. Mass.:
431.507
SMILES:
COC(=O)c1ccc(cc1)C(O)c1cccc(c1)C(C#N)C(=N)Sc1ccccc1N
Structure:
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