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Target
Endothelin-1 receptor
Ligand
BDBM50141472
Substrate
n/a
Meas. Tech.
ChEBML_65489
IC50
0.011000±n/a nM
Citation
 Takahashi, H; Ohtake, N; Sakamoto, T; Iino, T; Kawanishi, N; Nakamura, M; Yoshizumi, T; Niiyama, K; Ozaki, S; Okada, H; Kano, A; Takahashi, H; Ishii, Y; Okada, M; Saito, M; Sawazaki, Y; Hayama, T; Nishikibe, M Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines. Bioorg Med Chem Lett 14:1503-7 (2004) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50141472
Synonyms:
(5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-2-isopropylamino-7-[4-methoxy-2-(3-methoxy-2-methyl-propyl)-phenyl]-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL289634
Type:
Small organic molecule
Emp. Form.:
C31H36N2O6
Mol. Mass.:
532.6273
SMILES:
COCC(C)Cc1cc(OC)ccc1[C@H]1[C@@H]([C@H](c2ccc(NC(C)C)nc12)c1ccc2OCOc2c1)C(O)=O
Structure:
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