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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50575246
Substrate
n/a
Meas. Tech.
ChEMBL_2124799 (CHEMBL4834032)
IC50
0.590000±n/a nM
Citation
 Sabnis, RW Novel Substituted Piperazine Amide Compounds as Indoleamine-2,3-dioxygenase (IDO) Inhibitors. ACS Med Chem Lett 12:1639-1640 (2021) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50575246
Synonyms:
CHEMBL4879235
Type:
Small organic molecule
Emp. Form.:
C27H34FN5O3
Mol. Mass.:
495.589
SMILES:
[H][C@]12C[C@@]1([H])c1c(C2)n(CC(=O)N2CCN(CC2)c2cccc(C)c2C)nc1C(=O)N1CC[C@@H](O)[C@H](F)C1 |r|
Structure:
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