Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM17589
Substrate
n/a
Meas. Tech.
ChEBML_105136
IC50
370±n/a nM
Citation
Sheppard, GS; Wang, J; Kawai, M; BaMaung, NY; Craig, RA; Erickson, SA; Lynch, L; Patel, J; Yang, F; Searle, XB; Lou, P; Park, C; Kim, KH; Henkin, J; Lesniewski, R 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg Med Chem Lett 14:865-8 (2004) [PubMed] Article
More Info.:
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
Inhibitor
Name:
BDBM17589
Synonyms:
(2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S)-1-(naphthalen-1-yl)ethyl]pentanamide | A311263 | CHEMBL352943 | bestatin-type inhibitor, 4
Type:
Small organic molecule
Emp. Form.:
C19H26N2O2S
Mol. Mass.:
346.487
SMILES:
CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r|