Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM50141746
Substrate
n/a
Meas. Tech.
ChEBML_105136
IC50
1600±n/a nM
Citation
 Sheppard, GS; Wang, J; Kawai, M; BaMaung, NY; Craig, RA; Erickson, SA; Lynch, L; Patel, J; Yang, F; Searle, XB; Lou, P; Park, C; Kim, KH; Henkin, J; Lesniewski, R 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg Med Chem Lett 14:865-8 (2004) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50141746
Synonyms:
(S)-3-Amino-2-hydroxy-N-((S)-1-naphthalen-1-yl-ethyl)-4-propylsulfanyl-butyramide | CHEMBL434491
Type:
Small organic molecule
Emp. Form.:
C19H26N2O2S
Mol. Mass.:
346.487
SMILES:
CCCSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: