Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50118470
Substrate
n/a
Meas. Tech.
ChEMBL_2125811 (CHEMBL4835156)
Ki
0.014000±n/a nM
Citation
 Hoashi, Y; Takai, T; Kosugi, Y; Nakashima, M; Nakayama, M; Hirai, K; Uchikawa, O; Koike, T Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist. J Med Chem 64:3059-3074 (2021) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50118470
Synonyms:
CHEMBL1218 | N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b | RAMELTEON | Rozerem
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.3434
SMILES:
CCC(=O)NCC[C@@H]1CCc2ccc3OCCc3c12
Structure:
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